UVB ‐ induced Interleukin‐18 production downregulated by Tannic acid

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Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation☆

Interleukin (IL)-4 is a critical stimulator that induces ɛ germline transcripts (ɛGT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced ɛGT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4Rα, JAK3 and STAT6. Furthermore, tannic acid,...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2006

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.20.4.a533